Dr. Wyse's obtained his Ph.D. in Pharmacology from McGill University in 1969 and did two years of postdoctoral research at the University of New Mexico before entering Medical School at the University of Calgary. After obtaining his MD in 1974, he did training in Internal Medicine at Foothills Hospital followed by Cardiology at Oregon Health Sciences University. He joined the Faculty of the University of Calgary in 1978, became Professor in 1985 and was the Chief of Cardiology from 1986 to 1993. He was Associate Dean (Clinical Affairs) from 1993-99. He became Professor Emeritus in 2005. Although originally a vascular biologist, Dr. Wyse is better known in the area of heart rhythm management, particularly atrial fibrillation. He was the lead investigator for the AFFIRM trial. He has also played a leadership role in the following AF trials: AF-CHF,ACTIVE, ADMADEUS, PACIFIC, CABANA, PAPA BEAR.